Digestive Enzyme Supplements for EPI

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Enzyme Diane EPI-Exocrine Pancreatic Insufficiency Enzymes

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About EPI and Enzyme Diane

My struggles in dealing with EPI started back in 2004 when my rescue German Shepherd Dog started losing weight and having very soft, large stools.  After a year of bad advice and vet appointments wewere relieved to have gotten a diagnosis in August 2005.  Like so many, the treatment prescribed was not the correct treatment for our dog. The bad advise almost cost Sarge his life.  In December 2005 in a last ditch effort to save Sarge I was directed to a group of caring people on the Yahoo group K9-EPIGlobal.  They listened to me day and night and made suggestions which I took back to another veterinarian.  Sarge was on the road to being stable.  You can read more about my journey with Sarge and see the documents I gave to my new Veterinarian HERE.   

Now you are dealing with your pet being diagnosed with Exocrine Pancreatic Insufficiency, EPI, you are stumped you want to stop the weight loss, the veterinarian has instructed you to purchase some very expensive digestive enzymes and give them with food.  You are encouraged that they figured out what was wrong with your pet but your head is still reeling from the costs associated with this disease.  I have been there, I know what it feels like and getting the diagnosis opens a flood of emotions. There is help just like the help I received.  I encourage you to join a support group,  You will find links to them HERE.  Believe it or not there are thousands of people that have been in your place with their pets.  Take advantage of these sites.  Being able to discuss what is going on with your pet with someone that has been there and done that cannot be underestimated. Taking this information back to your vet is a must.  Many of us would not have our dogs today without this support.  I thank each and every one of them that stayed up answering my questions.  You may have already visited a support group and that is why you are here.

Pancreatin is a porcine based digestive enzyme.  Think of it as the generic of Viokase V, Pancrezyme, Bio Case and other over the counter and prescription digestive enzymes at a fraction of the cost.  But will it work?  Yes, Pancreatin is an enzyme mixture derived from porcine pancreas glands.  It contains three principle enzymes: Protease, Amylase, and Lipase to digest starches, fats and protein.  Once your pets food is digested he can absorb the nutrients from it.  All food that is eaten will need to be treated with enzymes.  The dose depends on several factors and is different for each pet.  As an EPI dog owner you become very good at looking at your dogs stool to tell what is going on.  You will figure out what greasy stool means for your dog, what yellow stools mean and how to deal with each one of them. 

Dealing with EPI not only requires enzymes and a low fat, low fiber diet that is usually grain free but you may need to deal with Small Intestinal Bacterial Overgrowth, SIBO.  Bad bacteria loves to feed off the bad stools your dog has been having.  If you had the cTLI done the Folate part of the test will let you know if you need to treat for SIBO.  Please note research suggests that a 30 day course of antibiotics be used to kill this bacteria.  If antibiotics are prescribed remember DO NOT stop them just because the stools are looking better.  This bacteria can become stubborn.  So now that you are dealing with enzymes, diet and SIBO you may need to address Cobalamin or b12. In talking with EPI dog owners b12 is one of the most overlooked parts of dealing with EPI, do not make this mistake.  Low cobalamin can have several side effects.  Cobalamin (b12) aids in digestion and can be the difference between perfect poops and not so perfect poops.  If you dog is low or boarder line b12 supplementation via shots (or pills that contain an intrinsic factor) will need to be continued for the rest of the dogs life.  B12 shots are inexpensive and can be done at home.  You can find estimated costs of treating your EPI dog here

This site will not replace the care your veterinarian can provide for your EPI pet.  It is the stories and trials that I have faced over the years with my own dog.  I hope that by sharing this information you to may be on your way to having a stable, active pet.

My Dogs


2 of our current dogs both rescues Molly and Si along with Diane competing for our very first time in obedience at the Crown Classic dog show in Cleveland, Ohio. -Photo courtesy of Pat an EPI dog owner.


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  • "Our Liver color GSP "Zac" sucked down a full stick of butter about 10 years ago. I'm told this may be the reason he has pancreatic problems. None the less, he is a trim 105 lbs ..."
    Life Saver!
  • "One year after our "CairnRescue".. terrier, Libby, arrived... after being nothing but a producer of puppies in her life... Libby developed EPI (not diagnosed by our usual vet....."
    Sheafe Ewing
    Libby , now 12, is a dog wonder


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